SAN DIEGO (AP) _ Jeff Garcia and the San Francisco 49ers quickly brought the San Diego Chargers back to reality.

One week after the Chargers snapped their 11-game losing streak, they lost 45-17 to San Francisco on Sunday to tie the team record with their 12th loss.

Garcia threw two touchdown passes to Jerry Rice, and with 323 yards had his fourth 300-yard game of the season. The 49ers, coming off their bye week, won their third straight game and their 45 points were a season-high. Garcia had no touchdown passes in the previous two victories.

San Francisco (5-8) has beaten the Chargers six straight times, twice since embarrassing them 49-26 in the 1995 Super Bowl.

Garcia threw a 1-yard scoring pass to Rice as the 49ers scored 17 straight points in the second quarter to take the lead for good. Garcia threw a 12-yard touchdown pass to Rice midway through the fourth quarter, on the first play after Monty Montgomery intercepted Ryan Leaf.

The remnants of the crowd of 57,255, many of them 49ers fans, saluted the NFL's career leading receiver with chants of ``Jerry! Jerry! Jerry!''

Garcia completed 18 of 32 passes. Leaf had a horrible fourth quarter, throwing interceptions on four straight possessions. Montgomery and Zack Bronson had two apiece, with Montgomery returning a pickoff 46 yards for a touchdown with 1:39 left.

Three Chargers quarterbacks have combined for an NFL-high 27 interceptions, with Leaf throwing 15. Leaf was 24-of-47 for 266 yards.

The Chargers set the franchise record with 12 losses in 1975, then matched it in 1986, 1997 and this year.

After falling behind 7-0 on Terrell Fletcher's 7-yard run midway through the first quarter, Garcia led the 49ers on three straight scoring drives in the second quarter. He threw five passes of 28 yards or longer in the first half, connecting for big plays on each of the scoring drives.

He threw a 34-yarder over the middle to tight end Greg Clark to set up Wade Richey's 22-yard field goal, then hit J.J. Stokes on a 53-yarder down the left sideline that led to a 1-yard TD run by Fred Beasley for a 10-7 lead.

Garcia then had completions of 28 yards to Rice and 39 yards to Tai Streets on the drive that Rice finished by catching a 1-yard pass in the right front corner of the end zone for a 17-7 lead with 1:10 left in the quarter.

John Carney kicked a 34-yard field goal to pull the Chargers to 17-10 at halftime.

The 49ers put the game out of reach in the third quarter, with a 28-yard field goal by Richey and a 4-yard run by Charlie Garner to make it 27-10. Garner's TD was set up when Bronson forced tight end Freddie Jones to fumble, which safety Lance Schulters recovered and returned 16 yards to the San Diego 15.

Garcia hit Terrell Owens on a 43-yarder to set up Richey's 38-yard field goal with 9:23 left.

Leaf threw a 17-yard pass to Curtis Conway early in the fourth quarter before throwing the four interceptions.