SAN FRANCISCO (AP) -- It didn't matter that the Carolina Panthers' revamped defense came together. The offense had already taken care of the San Francisco 49ers.

Steve Beuerlein threw for 364 yards and three touchdowns as the Panthers beat the 49ers 38-22 on Sunday.

Former 49ers running back William Floyd opened the game with a 1-yard touchdown run and Tshimanga Biakabutuka ran for another as the Panthers' offense made up for a sloppy season-opening loss to Washington.

A halftime celebration honored former San Francisco greats Joe Montana, Ronnie Lott and Dave Wilcox, but the 49ers on the field bore no resemblance to their storied predecessors.

All of San Francisco's touchdowns came in the second half. Terry Jackson ran from 1-yard out to open the second half, and J.J. Stokes caught a 17-yard scoring pass from Rick Mirer midway through the final quarter. Inside the two-minute warning, fullback Fred Beasley had a 2-yard TD run.

The 49ers, who lost last weekend in Atlanta, had won their past seven home openers.

With former 49ers coach George Seifert now in charge at Carolina, the Panthers took full advantage of their familiarity with San Francisco.

On the opening series, Beuerlein hit on his first three passes -- including a 21-yard pass to a wide open Wesley Walls -- to take the Panthers down to San Francisco's 1. Floyd ran over safety Pierson Prioleau for the touchdown, putting Carolina up 7-0.

Beuerlein was equally effective on his next series, capping it with a 24-yard touchdown pass to Donald Hayes.

The 49ers bumbled their way through the first half on both sides of the ball. But the offense was completely stopped by the Panthers' new-look defense featuring offseason acquisitions Reggie White, Eric Swann and another former 49ers player, Lee Woodall.

The new group, which looked disorganized last weekend against the Redskins, had a sack and forced a fumble. But its strength was keeping San Francisco out of the end zone.

The 49ers, meanwhile, didn't help themselves.

Late in the first quarter, Terrell Owens caught a short pass from Jeff Garcia and ran 53 yards down the sideline. Caught by several Carolina defenders, Owens fumbled on 1, and it tumbled through the end zone and out of bounds for a touchback.

Julian Peterson, San Francisco's top draft pick, intercepted Beuerlein's pass in the second quarter, but the 49ers' offense wasn't able to move the ball.

The Panthers took just five plays to move 72 yards on the next series, and Beuerlein hit Mushin Muhammad with a 3-yard touchdown pass despite two 49ers in front of him in the end zone.

Before the half, Beuerlein hit Muhammad with a 36-yard pass that he fumbled before it fell out of bounds at the 2. Biakabutuka later ran it in for the touchdown.

Beuerlein connected with Walls on a 9-yard touchdown pass, and Richie Cunningham added a 24-yard field goal for the Panthers in the third quarter.

Garcia, who was replaced by Mirer in the fourth, finished 12-of-20 for 181 yards and an interception.

Beuerlein was 24-of-32 and was intercepted once.

Seifert coached the 49ers to two Super Bowl championships and six NFC West titles, with stars such as Montana, Lott, Steve Young and Jerry Rice.