49ers All-Time First Round Picks
| Year | Player | Pos. | School |
| 2001 | Andre Carter | DE | California |
| 2000 | Julian Peterson | LB | Michigan St. |
| 1999 | Reggie McGrew | DT | Florida |
| 1998 | R.W.McQuarters | CB | Oklahoma St. |
| 1997 | Jim Druckenmiller | QB | Virginia Tech |
| 1996 | No Pick | ||
| 1995 | J.J. Stokes | WR | UCLA |
| 1994 | Bryant Young
William Floyd |
DT
RB |
Notre Dame
Florida St. |
| 1993 | Dana Stubblefield
Tod Kelly |
DE
DE |
Kansas
Tennessee |
| 1992 | Dana Hall | S | Washington |
| 1991 | Ted Washington | NT | Louisville |
| 1990 | Dexter Carter | RB | Florida St. |
| 1989 | Keith DeLong | LB | Tennessee |
| 1988 | No Pick | ||
| 1987 | Harris Barton | T | North Carolina |
| 1986 | No Pick | ||
| 1985 | Jerry Rice | WR | Mississippi Valley St. |
| 1984 | Todd Shell | LB | Brigham Young |
| 1983 | No Pick | ||
| 1982 | No Pick | ||
| 1981 | Ronnie Lott | CB | Southern California |
| 1980 | Earl Cooper
Jim Stuckley |
RB
DE |
Rice
Clemson |
| 1979 | No Pick | ||
| 1978 | Ken McAfee
Dean Buntz |
TE
LB |
Notre Dame
Long Beach St. |
| 1977 | No Pick | ||
| 1976 | No Pick | ||
| 1975 | Jimmy Webb | DT | Mississippi St. |
| 1974 | Wilbur Jackson
Bill Sandifer |
RB
DT |
Alabama
UCLA |
| 1973 | Mike Holmes | CB | Texas Southern |
| 1972 | Terry Beasley | WR | Auburn |
| 1971 | Tim Anderson | CB | Ohio St. |
| 1970 | Cedrick Hardman | DE | North Texas St. |
| 1969 | Ted Kwalick | TE | Penn St. |
| 1968 | Forrest Blue | C | Auburn |
| 1967 | Steve Spurrier | QB | Florida |
| 1966 | Stan Hindman | DE | Mississippi |
| 1965 | Ken Willard
George Donnelly |
RB
DB |
North Carolina
Illinois |
| 1964 | Dave Parks | WR | Texas Tech |
| 1963 | Kermit Alexander | RB | UCLA |
| 1962 | Lance Alworth | WR | Arkansas |
| 1961 | Jimmy Johnson
Bernie Casey Bill Kilmer |
HB
FB QB |
UCLA
Bowling Green UCLA |
| 1960 | Monty Stickles | TE | Notre Dame |
| 1959 | Dave Baker
Dan James |
HB
C |
Oklahoma
Ohio St. |
| 1958 | Jim Pace
Charlie Kruger |
HB
OT |
Michigan
Texas A&M |
| 1957 | John Brodie | QB | Stanford |
| 1956 | Earl Morrall | QB | Michigan St. |
| 1955 | Dick Moegle | HB | Rice |
| 1954 | Bernie Faloney | QB | Maryland |
| 1953 | Harry Bobcock
Tom Stolhandske |
E
E |
Georgia
Texas |
| 1952 | Hugh McElhenny | RB | Washington |
| 1951 | Y.A.Tittle | QB | Louisiana St. |
| 1950 | Leo Nomellini | OT | Minnesota |
